Full list of publications available through PubMed or Google Scholar.


  1. Botuyan MV, Cui G, Drane P, Detappe A, Brault ME, Parnandi N, Chaubey S, Thompson JR, Bragantini B, Zhao D, Chapman JR, Chowdhury D, Mer G “Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein” Nat Struct Mol Biol. 2018 Jul 2.
  2. Detappe A, Bustoros M, Mouhieddine TH, Ghoroghchian PP “Advancements in Nanomedicine for Multiple Myeloma.” Trends Mol Med. 2018 Jun 24.
  3. Meghani K, Fuchs W*, Detappe A*, Drane P, Gogola E, Rottenberg S, Jonkers J, Matulonis U, Swisher EM, Konstantinopoulos PA, Chowdhury D “Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.” Cell Rep. 2018 Apr 3.
  4. Kurdi A, Glavey S, Bezman NA, Jhatakia A, Guerriero JL, Manier S, Moschetta M, Mishima Y, Roccaro A, Detappe A, Liu CJ, Sacco A, Huynh D, Tai YT, Robbins MD, Azzi J, Ghobrial IM “Antibody dependent cellular phagocytosis by macrophages is a novel mechanism of action of elotuzumab” Mol Cancer Ther. 2018 Apr 13.
  5. Zhimin T, Muzumbar M, Detappe A, Huang X, Xu E, Yu Y, Mouhieddine TH, Haiqin S, Jacks T, Ghoroghchian PP “Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer.” Nano Lett. 2018 Mar 13.
  6. Ghobrial IM, Detappe A, Anderson KC, Steensma DP “The bone marrow niche in myelodysplastic syndromes (MDS) and monoclonal gammopathy of undetermined significance (MGUS): Implications for acute myeloid leukemia (AML) and multiple myeloma (MM).” Nat Rev Clin Oncol. 2018 Jan 9.
  7. Qi R, Wang Y, Bruno P, Xiao H, Yu Y, Li T, Lauffer S, Wei W, Chen Q, Kang X, Song H, Yang X, Huang X, Detappe A, Matulonis U, Pepin D, Hemann MT, Birrer MJ, Ghoroghchian PP “Nanoparticle-conjugates of a Highly Potent Toxin Enhance Safety and Circumvent Platinum Resistance in Ovarian Cancer.” Nat Commun. 2017 Dec 18;8(1):2166.
  8. Hofmann CL, O’Sullivan MC, Detappe A, Yu Y, Yang X, Qi W, Landon CD, Therien MJ, Dewhirst MW, Ghoroghchian PP, Palmer GM “NIR-emissive PEG-b-TCL Micelles for Breast Tumor Imaging and Minimally Invasive Pharmacokinetic Analysis.” Nanoscale 2017 Sep 21;9(36):13465-13476.
  9. Bustoros M, Mouhieddine TH, Detappe A, Ghobrial IM “Established and novel prognostic biomarkers in multiple myeloma.” Am Soc Clin Oncol Educ Book. 2017;37:548-560.
  10. Y. Mishima, B. Paiva, J. Shi, J. Park, S. Manier, S. Takagi, M. Massoud, A. Perilla-Glen, Y. Aljawai, D. Huyn, A.M. Roccaro, A. Sacco, M. Capellitti, A. Detappe, D. Aligani, K.C. Anderson, N.C. Munshi, F. Prosper, J. Lohr, G. Ha, S. Freeman, E.M. Van Allen, V. Adalsteinsson, F. Michor, J.F. San Miguel, I.M. Ghobrial “The mutational landscape of circulating tumor cells in Multiple Myeloma.” Cell Rep. 2017 Apr 4;19(1):218-224
  11. A. Detappe, E. Thomas, M.W. Tibbitt, S. Kunjachan, O. Zavidij, N. Parnandi, E. Reznichenko, F. Lux, O. Tillement, R. Berbeco “Ultrasmall Silica-based Bismuth Gadolinium nanoparticle for dual MR-CT image-guided radiation therapy.” Nano Lett., Nano Lett. 2017 Mar 8;17(3):1733-1740
  12. P. Drané, M.E. Brault, G. Cui, K. Meghani, S. Chaubey, A. Detappe, N. Parnandi, Y.Z. He, X.F. Zhang, M.V. Botuyan, A. Kalousi, W.T. Yewdell, C. Münch, J.W. Harper, J. Chaudhuri, E. Soutoglou, G. Mer, D. Chowdhury “TIRR regulates 53BP1 by masking its histone methyl-lysine binding function” Nature. 2017 Mar 9;543(7644):211-216.
  13. A. Detappe, S. Kunjachan, P. Drané, S. Kotb, M. Myronakis, D. Biancur, T. Ireland, M. Wagar, F. Lux, O. Tillement, R. Berbeco “Key clinical beam parameters for nanoparticle-mediated radiation dose amplification.” Sci Rep. 2016 Sep 23;6:34040
  14. A. Detappe, S. Kunjachan, L. Sancey, V. Motto-Ros, D. Biancur, P. Drane, R. Guieze, O. Tillement, R. Langer, R. Berbeco “Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy.” J Control Release. 2016 Jul 14;238:103-113
  15. G. Appelboom, A. Detappe, M. Lopresti, S. Kunjachan, S. Chang, O. Tillement “Stereotactic modulation of blood brain barrier permeability to enhance drug delivery.” Neuro Oncol. 2016 Jul 11
  16. A. Detappe, F. Lux, and O. Tillement. “Pushing radiation therapy limitations with theranostic nanoparticles.” Nanomedicine (Lond), Apr 2016.
  17. S. Kotb, A. Detappe, F. Lux, F. Appaix, E. L. Barbier, V. L. Tran, M. Plissonneau, H. Gehan, F. Lefranc, C. Rodriguez-Lafrasse, C. Verry, R. Berbeco, O. Tillement, and L. Sancey “Gadolinium- based nanoparticles and radiation therapy for multiple brain melanoma metastases: proof of concept before phase 1 trial.” Theranostics, 6(3):418–427, 2016.
  18. S. Mitrasinovic, G. Appelboom, A. Detappe, and E. Sander Connolly “Focused ultrasound to transiently disrupt the blood brain barrier.” J Clin Neurosci, Feb 2016.
  19. R. I. Berbeco, A. Detappe, P. Tsiamas, D. Parsons, M. Yewondwossen, and J. Robar “Low Z target switching to increase tumor endothelial cell dose enhancement during gold nanoparticle-aided radiation therapy.” Med Phys, 43(1):436, Jan 2016.
  20. S. Kunjachan, A. Detappe, R. Kumar, T. Ireland, L. Cameron, D. E. Biancur, V. Motto-Ros, L. Sancey, S. Sridhar, G. M. Makrigiorgos, and R. I. Berbeco “Nanoparticle mediated tumor vascular disruption: A novel strategy in radiation therapy.” Nano Lett., 15(11):7488–7496, Nov 2015.
  21. A. Detappe, S. Kunjachan, J. Rottmann, J. Robar, P. Tsiamas, H. Korideck, O. Tillement, and R. Berbeco “AGuIX nanoparticles as a promising platform for image-guided radiation therapy.” Cancer Nanotechnol, 6(1):4, 2015.
  22. F. Lux, A. Detappe, S. Dufort, L. Sancey, C. Louis, S. Carme, and O. Tillement “[Ultrasmall nanoparticles for radiotherapy: AGuIX].” Cancer Radiother, 19(6-7):508–514, Oct 2015.
  23. Y. Altundal, G. Cifter, A. Detappe, E. Sajo, P. Tsiamas, P. Zygmanski, R. Berbeco, R. A. Cormack, M. Makrigiorgos, and W. Ngwa “New potential for enhancing concomitant chemoradiotherapy with FDA approved concentrations of cisplatin via the photoelectric effect.” Phys Med., 31(1):25–30, Feb 2015.
  24. L. Sancey, F. Lux, S. Kotb, S. Roux, S. Dufort, A. Bianchi, Y. Cremillieux, P. Fries, J. L. Coll, C. Rodriguez-Lafrasse, M. Janier, M. Dutreix, M. Barberi-Heyob, F. Boschetti, F. Denat, C. Louis, E. Porcel, S. Lacombe, G. Le Duc, E. Deutsch, J. L. Perfettini, A. Detappe, C. Verry, R. Berbeco, K. T. Butterworth, S. J. McMahon, K. M. Prise, P. Perriat, and O. Tillement “The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy.” Br J Radiol, 87(1041):20140134, Sep 2014.
  25. A. Detappe, P. Tsiamas, W. Ngwa, P. Zygmanski, M. Makrigiorgos, and R. Berbeco “The effect of flattening filter free delivery on endothelial dose enhancement with gold nanoparticles.” Med Phys., 40(3):031706, Mar 2013.


  1. Kunjachan S, Kotb S, Kumar R, Pola R, Pechar M, Gremse F, Taleei R, Trichard F, Motto-Ros V, Sancey L, Detappe A, Protti A, Shanmugam I, Ireland T, Etrych T, Sridhar S, Tillement O, Makrigiorgos M, Berbeco R “Enhanced Drug Delivery by Nanoparticle and Radiation-mediated Tumor Vascular Modulation.” Submitted
  2. Xiao H, Li T, Wang Y, Qi R, Yu Y, Lauffer S, Chen Q, Yang X, Kang X, Song H, Wei W, Detappe A, Matulonis U, Birrer MJ, Ghoroghchian PP “Combined Delivery of CRISPR/Cas9 and Small Molecule Anticancer Agents Potentiates Therapeutic Activity.” Submitted
  3. Ghoroghchian PP, Hofmann CL, Yewle JN, Tao Z, Barrett C, Loas A, Spiegel A, Rohlfing AB, O’Sullivan MC, Wang Y, Detappe A, Ostertag EM, Therien MJ, Yaffe MB, Lippard SJ, Dewhirst MW, Palmer GM “Polymersome-encapsulated Myoglobin Promotes Tumor Regression Through Microvascular Collapse.” Submitted
  4. Nguyen HVTN*, Detappe A*, Gallagher N, Zhang H, Harvey P, Yan C, Mathieu C, Golder MR, Jiang Y, Jasanoff A, Rajca A, Ghobrial IM, Ghoroghchian PP, Johnson JA “High-loading Nitoxide-based Macromolecular Contrast Agents Allows for MRI Millimetric Tumor Detection.” Submitted
  5. Detappe A, Reidy M, Yu Y, Mathieu C, Nguyen HVT, Coroller TP, Lam F, Jarolim P, Tillement O, Johnson JA, Ghoroghchian PP, Ghobrial IM “Antibody-targeted Gadolinium Nanoparticle Enhances Imaging Sensitivity and Enables Longitudinal Tracking of Multiple Myeloma.” Submitted
  6. Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Sanaagata S, Whitesell L, Markely JL, Ghobrial IM, Sabatini DM, Lindquist S “FDX1 Inhibition Prevents Adaptation to Proteotoxic Stress by Blocking the Glyocolysis-OXPHOS shift in Cancers.” Submitted